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My lab uses a combination of computational biology and high throughput genomics techniques to identify functional elements in the genome. We seek to understand recognition events important in gene expression (i.e transcription and RNA splicing). Specific projects include 1) understanding how particular arrangements of sequence elements are read by the splicing machinery, 2) identifying mutations/polymorphisms that disrupt splicing in the human population and 3) Defining combinatorial interactions between transcription factors (mostly Oct and Forkhead factors) that help maintain the pluripotent state of embryonic stem cells (ES cells).


a reading list of relevant papers ...

 

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